With more than 100 pneumococcal serotypes in circulation, new pneumococcal conjugate vaccines containing serotypes are needed to address the changing pneumococcal serotype epidemiological landscape. Merck & Co. developed a new pneumococcal reference standard (MPRSS-01) containing serotype-specific IgG concentrations for 24 serotypes from the existing standard (007sp), as well as with an additional nine novel serotypes. The antibody concentrations for the 24 established serotypes in MPRSS-01 were assigned via direct calibration to the existing standard, while a cross-standardization approach was used for the nine novel serotypes. The calibration study demonstrated parallelism of the dilution-response curves across the 33 serotypes between MPRSS-01 and 007sp, allowing the use of any 007sp-assigned serotype as a reference calibrator.
Antonello JM, Murphy RD, Abeygunawardana C, Malinverni JC, Gowrisankar R, Green T, Greway R, Schmauch J, Howlett A, Bonhomme CJ, Nolan KM. Establishing a new human pneumococcal standard reference serum, MPRSS-01. mSphere. 2025 Jan 28;10(1):e0040424. doi: 10.1128/msphere.00404-24. Epub 2025 Jan 7. PMID: 39772874; PMCID: PMC11774022. https://journals.asm.org/doi/10.1128/msphere.00404-24
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