Rowan: Postbiotic Metabolites Against Pseudomonas Infection

Treating Pseudomonas aeruginosa wound infections are challenging due to biofilm formation and antibiotic resistance.  This motivated Kingsley Yin’s lab at Rowan University to explore Lactobacillus acidophilus postbiotic metabolites as a potential therapeutic alternative.  Lactobacillus acidophilus postbiotic (LaP) reduced Pseudomonas aeruginosa bacterial burden in a mouse wound infection model 24 hours and 5 days after infection.  LaP increased anti-inflammatory IL-10 levels in wound tissue after 5 days of infection and stimulated monocyte adherence in vitro, suggesting it may promote wound healing.  LaP reduced pathogen load and modulated the inflammatory response in a mouse wound infection model.  The potential bioactive molecule is likely a low molecular weight, polar metabolite with a m/z of 295.1369.

Wilson RM, Walker JM, Beld J, Yin K. Lactobacillus acidophilus (strain Scav) postbiotic metabolites reduce infection and modulate inflammation in an in vivo model of Pseudomonas aeruginosa wound infection. J Appl Microbiol. 2025 Mar 3;136(3):lxaf061. doi: 10.1093/jambio/lxaf061. PMID: 40068933; PMCID: PMC11951090. 

https://academic.oup.com/jambio/article/136/3/lxaf061/8071230