Our colleagues in the Subbian Lab at Public Health Research Institute, New Jersey Medical School, Rutgers University, found the Mycobacterium tuberculosis (Mtb) population in rabbit lungs consists of at least two semi-independent sub-populations with different replication and death kinetics, which they propose could be due to differences in the lung environment or immune response, and they suggest future research should explore Mtb growth dynamics in granulomas using the pBP10 plasmid in different Mtb strains and animal models.
Ganusov VV, Kolloli A, Subbian S (2024) Mathematical modeling suggests heterogeneous replication of Mycobacterium tuberculosis in rabbits. PLoS Comput Biol 20(11): e1012563. https://doi.org/10.1371/journal.pcbi.1012563
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